Harnessing the Power of Autophagy
to Restore Health and Cure Disease

PAQ Approach

PAQ’s global team is pioneering a new approach to restoring health and curing disease through autophagy, the body’s most versatile mechanism for natural cellular degradation. We are developing a new class of small molecule degradation therapies by expanding the ability to directly target and eliminate disease-causing entities beyond proteins.

Our Technology

PAQ’s platform is driven by autophagosome-tethering compounds (ATTECs), small molecules with the potential to catalyze and selectively enhance the degradation of disease-causing entities through autophagy. Using this powerful platform, PAQ has the potential to identify and design novel therapies to deliver on the promise of autophagy with the goal of overcoming serious diseases that have limited or no treatment options.

PAQ’s initial focus is on a genetic neurodegenerative disorder with no current treatment options for patients. PAQ plans to expand the ATTEC platform to target additional disease-causing protein and non-protein targets.

Our Team

PAQ’s expert team of global scientists, entrepreneurs and world-class scientific advisors are committed to broadening therapeutic horizons driven by advances in autophagy.

Nan Ji, PhD
Co-Founder, President and CEO
Huaixiang Hao, PhD
Co-founder and Head of Biology
Boxun Lu, PhD
Scientific Founder
David Rubinsztein, MB ChB, PhD, FRS, FMedSci
Scientific Advisory Board Member
Jared Rutter, PhD
Scientific Advisory Board Member
James B. Summers, PhD
Scientific Advisory Board Member
Jin-Quan Yu, PhD
Scientific Advisory Board Member

Join Us

Based in Cambridge, Massachusetts, our team is visionary, enthusiastic and united in our commitment to help patients overcome devastating disease through the power of autophagy. Join us as we work together to achieve the full potential of our research and realize the promise of a new therapeutic approach for patients.

Learn more about open positions
Contact Us




PAQ Therapeutics

100 Summit Drive, Suite 916

Burlington, MA 01803, USA

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