Associate Director to Director, Biology

Cambridge, MA

A great opportunity to grow your career with an exciting, early-stage company! The Associate Director/Director, Biology, will be responsible for leading drug discovery programs by applying autophagy-mediated degradation of proteins and non-protein targets. In collaboration with chemistry leaders and a multidisciplinary team, this individual will define the project strategy, and implement assays and in vitro and in vivo models to refine understanding of the target in disease/TPP and drive hit-to-lead/lead-optimization work towards the identification of differentiated development candidates. She/he will direct and prioritize efforts at both contract research organizations and PAQ’s lab to address key scientific questions and drive progression within aggressive timelines.

PAQ Therapeutics is an early-stage biotechnology company pioneering a new approach to restoring health and curing disease through autophagy, the body’s most versatile mechanism for natural cellular degradation. We are developing a new class of small molecule degradation therapies by expanding the ability to directly target and eliminate disease-causing entities. PAQ Therapeutics recently completed $30 million in Series A financing.


  • Lead/co-lead small molecule drug discovery programs from hit-to-lead to Development Candidate selection in collaboration with medicinal chemistry, pharmacology and structural biology colleagues.
  • Collaborate on design and implementation of efficient compound testing scheme and supervise development of critical biological assays.
  • Lead efforts to understand biological mechanisms of action, develop therapeutic hypotheses, achieve scientific proof-of-concept and identify biomarkers for target engagement.
  • Lead productive discussions and meetings on key scientific questions and strategies with internal and external colleagues at all levels and across disciplines.
  • Proactively identifies issues within the project and leads the team to cross-functional solutions to drive project decisions.
  • Rapidly adapt to changing project priorities and manage multiple projects simultaneously.


  • PhD in Cell Biology or Molecular Biology or Biochemistry, or related discipline with a minimum of 5 years of drug discovery experience, including demonstrated leadership of biology and project teams in the biotechnology industry.
  • In-depth knowledge of cell biology and common techniques used to evaluate mechanisms of action of small molecule compounds.
  • Attention to details and proven track record in handling, analyzing, and presenting experimental data to drive decision making.
  • Excellent verbal and written communication skills and presentation skills.
  • Ability to collaborate effectively within a fast-paced, multidisciplinary project team.
  • Experience in managing internal and external scientists at CRO preferred.